Preprint Review Version 1 This version is not peer-reviewed

Hypoxia and Chromatin, a Focus on Transcriptional Repression Mechanisms

Version 1 : Received: 28 February 2018 / Approved: 1 March 2018 / Online: 1 March 2018 (06:36:57 CET)

A peer-reviewed article of this Preprint also exists.

Batie, M.; del Peso, L.; Rocha, S. Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms. Biomedicines 2018, 6, 47. Batie, M.; del Peso, L.; Rocha, S. Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms. Biomedicines 2018, 6, 47.

Journal reference: Biomedicines 2018, 6, 47
DOI: 10.3390/biomedicines6020047

Abstract

Hypoxia, or reduced oxygen availability, has been studied extensively for its ability to activate specific genes. Hypoxia induced gene expression is mediated by the HIF transcription factors, although not exclusively so. Despite the great knowledge on the mechanisms by which hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms, but also the potential roles of dioxygenases with functions at the nucleosome and DNA level. Finally, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia.

Subject Areas

hypoxia; chromatin; transcriptional repression; repressor complexes; JmjC; histone methylation; HIF

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