Preprint Review Version 1 This version not peer reviewed

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B

Version 1 : Received: 1 November 2017 / Approved: 1 November 2017 / Online: 1 November 2017 (05:27:28 CET)

A peer-reviewed article of this Preprint also exists.

Bonser, L.R.; Erle, D.J. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J. Clin. Med. 2017, 6, 112. Bonser, L.R.; Erle, D.J. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J. Clin. Med. 2017, 6, 112.

Journal reference: J. Clin. Med. 2017, 6, 112
DOI: 10.3390/jcm6120112

Abstract

Asthma is characterized by mucus abnormalities. Airway epithelial metaplasia results in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired culminating in mucus plugging and airway obstruction, a major cause of morbidity in asthma. The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus. MUC5AC and MUC5B gene expression is altered in asthma and recent work sheds light on their contribution to asthma pathogenesis. Herein we review our current understanding of the role of MUC5AC and MUC5B in mucus dysfunction in asthma.

Subject Areas

MUC5AC; MUC5B; asthma

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