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Airway Mucus and Asthma: The Role of MUC5AC and MUC5B
Version 1
: Received: 1 November 2017 / Approved: 1 November 2017 / Online: 1 November 2017 (05:27:28 CET)
A peer-reviewed article of this Preprint also exists.
Bonser, L.R.; Erle, D.J. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J. Clin. Med. 2017, 6, 112. Bonser, L.R.; Erle, D.J. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J. Clin. Med. 2017, 6, 112.
Abstract
Asthma is characterized by mucus abnormalities. Airway epithelial metaplasia results in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired culminating in mucus plugging and airway obstruction, a major cause of morbidity in asthma. The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus. MUC5AC and MUC5B gene expression is altered in asthma and recent work sheds light on their contribution to asthma pathogenesis. Herein we review our current understanding of the role of MUC5AC and MUC5B in mucus dysfunction in asthma.
Keywords
MUC5AC; MUC5B; asthma
Subject
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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