Wang, S.; Zhou, K.; Shi, X.; Chang, L.; Zhang, Y.; Yu, B.; Liu, H. Steroidal Dimer by001 Inhibits Proliferation and Migration of Esophageal Cancer Cells via Multiple Mechanisms. Preprints2017, 2017060128. https://doi.org/10.20944/preprints201706.0128.v1
APA Style
Wang, S., Zhou, K., Shi, X., Chang, L., Zhang, Y., Yu, B., & Liu, H. (2017). Steroidal Dimer by001 Inhibits Proliferation and Migration of Esophageal Cancer Cells via Multiple Mechanisms. Preprints. https://doi.org/10.20944/preprints201706.0128.v1
Chicago/Turabian Style
Wang, S., Bin Yu and Hongmin Liu. 2017 "Steroidal Dimer by001 Inhibits Proliferation and Migration of Esophageal Cancer Cells via Multiple Mechanisms" Preprints. https://doi.org/10.20944/preprints201706.0128.v1
Abstract
Following our previous success in identifying new steroid-based anticancer agents, we herein disclosed the structural requirements for retaining high potency against cancer cells and associated modes of action. The structurally novel steroidal dimer by001 inhibited growth of different esophageal cancer cells and colony formation at low micromolar levels, elevated cellular ROS levels and caused mitochondrial dysfunction. Mechanistic studies showed that by001 induced cell death through the mitochondria and death receptor-mediated apoptotic pathways and autophagy induction, as well as inhibited migration.
Keywords
steroidal dimer; steroidal N-heterocycles; antiproliferative activity; esophageal cancer cells
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
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