Version 1
: Received: 11 April 2017 / Approved: 11 April 2017 / Online: 11 April 2017 (10:51:06 CEST)
How to cite:
Xu, P.; Lin, J.; Lin, Q.; Zhu, D.; Tang, W.; Niu, Z.; Jian, M.; Wang, Y.; Liang, C.; Xu, J. Prognostic Significance of High Survivin Expression in Patients with Gastrointestinal Cancer: A Meta-Analysis. Preprints2017, 2017040062. https://doi.org/10.20944/preprints201704.0062.v1
Xu, P.; Lin, J.; Lin, Q.; Zhu, D.; Tang, W.; Niu, Z.; Jian, M.; Wang, Y.; Liang, C.; Xu, J. Prognostic Significance of High Survivin Expression in Patients with Gastrointestinal Cancer: A Meta-Analysis. Preprints 2017, 2017040062. https://doi.org/10.20944/preprints201704.0062.v1
Xu, P.; Lin, J.; Lin, Q.; Zhu, D.; Tang, W.; Niu, Z.; Jian, M.; Wang, Y.; Liang, C.; Xu, J. Prognostic Significance of High Survivin Expression in Patients with Gastrointestinal Cancer: A Meta-Analysis. Preprints2017, 2017040062. https://doi.org/10.20944/preprints201704.0062.v1
APA Style
Xu, P., Lin, J., Lin, Q., Zhu, D., Tang, W., Niu, Z., Jian, M., Wang, Y., Liang, C., & Xu, J. (2017). Prognostic Significance of High Survivin Expression in Patients with Gastrointestinal Cancer: A Meta-Analysis. Preprints. https://doi.org/10.20944/preprints201704.0062.v1
Chicago/Turabian Style
Xu, P., Chunmin Liang and Jianmin Xu. 2017 "Prognostic Significance of High Survivin Expression in Patients with Gastrointestinal Cancer: A Meta-Analysis" Preprints. https://doi.org/10.20944/preprints201704.0062.v1
Abstract
Previous studies on the prognostic impact of survivin expression in gastrointestinal (GI) cancer have yielded inconsistent results. This study was initiated to assess the relationship between survivin expression and overall survival (OS) or disease free survival (DFS) in GI cancer patients. We applied system literature searches on EMBASE, PubMed, Web of science, and the Cochrane library to conduct this up-to-date meta-analysis. Thirty studies with totally 3622 GI cancer patients were collected. The prevalence of high survivin expression in GI cancer was 0.57 (95% CI: 0.51-0.63). High survivin expression was significantly associated with shorter OS (HR 1.57, 95% CI: 1.42-1.74) and DFS (HR 1.38, 95% CI: 1.21-1.58). Subgroup analysis also showed significant association between high survivin expression and poorer OS or DFS in gastric cancer or colorectal cancer. In summary, our study indicated that high survivin expression was related to poor prognosis in GI cancer. Well-designed studies with large sample and more convincing data are needed to confirm our conclusion.
Keywords
survivin; high expression; gastrointestinal cancer; prognostic
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
