Ginkgo Biloba for Reducing Hyperlipideamia : Case

Hyperlipidemia case was described as a rise of lipid profile or lipoproteins in the blood. This study describe briefly investigate the reducing hyperlipideamia impact of Ginkgo biloba on the level of lipid profile. Key word: GINKGO, hyperlipideamia, lipid profile.

circulations through maintaining the elasticity with the strength of the both large blood vessels and capillaries.It became easier for the blood and oxygen to reachs the extremity or organ properties through the fine capillaries.Lactones (Terpene), that were specific to ginkgo biloba, could inhibits PAF (platelet activating factors).Specifically, ginkgolide B has been appeared to PAF recepotors.It is considered as a dynamic and practical constituent in biloba.[2] Logical investigations involving human subjects, institutionalized ginkgo biloba concentrate was to positively affect enhancing blood dissemination.The body had lipid contents in the cell layers.This properties make them defenseless against attacks and harmed by free-radicals.Oxidized lipid, for example, lipid peroxide, can change cells and layers prompting to the progressive loss of semi permeability.[3] Flavonoid glycosides with proanthaiocyanidines in GBE had cancer prevention agent bolster the body,s cell reinforcement protection framework fighting free radicals.In continuation of previous studies [4][5][6][7][8][9][10][11][12][13][14], herein we are reporting investigation started from the Ginkgo biloba as the active material for reducing level of lipid profile in human.

Experimental Section
This investigation represent the effects of Ginkgo ß-active supplement on the level of lipid profile was investigate.The subject used Ginkgo ß-active it is manufactured by a GMP pharmaceutical production facility, manufacturing is strictly controlled contains 120mg of standardized ginkgo bibola leaf extract ( extraction ratio 50:1), in scientifically-supported ration of 27% ginkgo flavonoid glycosides and 7% terpene lactones (ginkolides A,B,C and bilobalide content).Lipid profile measurement done with Reflotron plus EN device from German with reflation strip.The samples collected in 0, 30, 60, and 90 days the results revealed in the Fig. 1.The study reveals a significant reduction in serum cholesterol in all the Gingko biloba treated groups.Although Ginkgo used in some countries as a hypolipidemicagent, of its action on lipid profile [15].Flavonoids present in Ginkgo bilobamay be responsible for its antioxidant as well as hypolipidemic action.The present study, however, has not investigated the mechanism of action of Ginkgo biloba.This should be explored further in future studies.Ginkgo biloba, according to reports from the literature has not been used clinically as a lipid lowering agent .GBE and its flavonoid components --quercetin, kaempferol, and isorhamnetin are widely found in fruits and vegetables.They reduce the hepatic lipid accumulation and up-regulate the expression of CPT1A [16][17][18][19].In addition, physiological overexpression of this rate-limiting enzyme in vivo and in vitro was sufficient to prevent the fatty acid-induced lipid accumulation and even reduce insulin resistance [20,21].The majority of fatty acid oxidation in the liver occurs in mitochondria and is regulated by CPT1A.GBE and its flavonoid contents quercetin and kaempferol minus isorhamnetin lowered triglycerides without influencing CPT1A expression, which suggested there were alternative pathways at play.β-oxidation was also reported to occur in peroxisomes and microsomes [22].GBE had also been reported

Results and discussion
to up-regulate a suite of genes related to peroxisomes and microsomes oxidation in an NAFLD rat model, such as straight-chain acyl-CoA oxidase (Acox), PPARα, and cytochrome P450 enzymes, indicators of fatty acid consumption.Quercetin and kaempferol were also confirmed to affect partial genes [23][24][25][26][27]. Therefore, GBE and its flavonoids might increase CPT1A expression to promote β-oxidation in mitochondria, as well as in peroxisomes and microsomes.

Conclusion
In conclusion, the present findings have demonstrated that the Ginkgo biloba displays significant activities, in reducing level of lipid profile in human.These findings may be attributed to the numerous effects of the different flavonoids present in the Ginkgo biloba.

Figure ( 1 )
Figure(1) the change in the level of lipid profile during the study