Intestinal Organoids—Current and Future Applications

Andre M. C. Meneses; Kerstin Schneeberger; Hedwig S. Kruitwagen; Louis C. Penning; Frank G. van Steenbeek; Iwan Burgener; Bart Spee

doi:10.20944/preprints201608.0090.v1

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preprints.org > medicine and pharmacology > veterinary medicine > doi: 10.20944/preprints201608.0090.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Intestinal Organoids—Current and Future Applications

^* ,

Frank G. van Steenbeek

Iwan Burgener

Bart Spee

Version 1 : Received: 8 August 2016 / Approved: 9 August 2016 / Online: 9 August 2016 (11:38:04 CEST)

A peer-reviewed article of this Preprint also exists.

Meneses, A.M.C.; Schneeberger, K.; Kruitwagen, H.S.; Penning, L.C.; van Steenbeek, F.G.; Burgener, I.A.; Spee, B. Intestinal Organoids—Current and Future Applications. Vet. Sci. 2016, 3, 31. Meneses, A.M.C.; Schneeberger, K.; Kruitwagen, H.S.; Penning, L.C.; van Steenbeek, F.G.; Burgener, I.A.; Spee, B. Intestinal Organoids—Current and Future Applications. Vet. Sci. 2016, 3, 31.

Abstract

Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from various species, organs and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, current and future uses of this exciting new insight model to veterinary medicine field.

Keywords

intestinal organoids; dog; practical applications

Subject

Medicine and Pharmacology, Veterinary Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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