Version 1
: Received: 10 May 2024 / Approved: 15 May 2024 / Online: 15 May 2024 (13:16:46 CEST)
How to cite:
Samsidi, I. N. M.; Zulkiply, N.; Johari, N. A. Some Transmembrane Proteins Of Salmonella Typhimurium Are Potential Drug Targets: An In Silico Analysis. Preprints2024, 2024051047. https://doi.org/10.20944/preprints202405.1047.v1
Samsidi, I. N. M.; Zulkiply, N.; Johari, N. A. Some Transmembrane Proteins Of Salmonella Typhimurium Are Potential Drug Targets: An In Silico Analysis. Preprints 2024, 2024051047. https://doi.org/10.20944/preprints202405.1047.v1
Samsidi, I. N. M.; Zulkiply, N.; Johari, N. A. Some Transmembrane Proteins Of Salmonella Typhimurium Are Potential Drug Targets: An In Silico Analysis. Preprints2024, 2024051047. https://doi.org/10.20944/preprints202405.1047.v1
APA Style
Samsidi, I. N. M., Zulkiply, N., & Johari, N. A. (2024). Some Transmembrane Proteins Of Salmonella Typhimurium Are Potential Drug Targets: An In Silico Analysis. Preprints. https://doi.org/10.20944/preprints202405.1047.v1
Chicago/Turabian Style
Samsidi, I. N. M., Nawal Zulkiply and Nur Anisah Johari. 2024 "Some Transmembrane Proteins Of Salmonella Typhimurium Are Potential Drug Targets: An In Silico Analysis" Preprints. https://doi.org/10.20944/preprints202405.1047.v1
Abstract
Salmonella sp. is a globally prevalent organism responsible for causing salmonellosis, a foodborne illness. Salmonella Typhimurium represents a type of Salmonella sp. not associated with typhoid fever but capable of causing stomach and intestinal inflammation or severe infection. In the present study, 150 uncharacterized proteins of S. Typhimurium were randomly selected from UniProtKB and analyzed using TMHMM, PROSITE, STRING, DEG, and BLASTp. Results indicated that 32 uncharacterized proteins (21%) were predicted to be transmembrane proteins involved in various biological pathways. Among them, 30 transmembrane proteins were predicted to be essential and non-host homologous. This study's findings suggest their potential as drug targets against salmonellosis.
Keywords
Salmonella; transmembrane protein; drug targets; in silico
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
