Version 1
: Received: 14 May 2024 / Approved: 14 May 2024 / Online: 15 May 2024 (10:29:30 CEST)
How to cite:
Lubinski, B.; Whittaker, G. R. Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review. Preprints2024, 2024050992. https://doi.org/10.20944/preprints202405.0992.v1
Lubinski, B.; Whittaker, G. R. Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review. Preprints 2024, 2024050992. https://doi.org/10.20944/preprints202405.0992.v1
Lubinski, B.; Whittaker, G. R. Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review. Preprints2024, 2024050992. https://doi.org/10.20944/preprints202405.0992.v1
APA Style
Lubinski, B., & Whittaker, G. R. (2024). Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review. Preprints. https://doi.org/10.20944/preprints202405.0992.v1
Chicago/Turabian Style
Lubinski, B. and Gary R. Whittaker. 2024 "Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review" Preprints. https://doi.org/10.20944/preprints202405.0992.v1
Abstract
Viral tropism is most commonly linked to receptor use, but host cell protease use can be a notable factor in susceptibility to infection. Here we review the use of host cell proteases by human viruses, focusing on those with primarily respiratory tropism, particularly SARS-CoV-2. We first describe the various classes of proteases present in the respiratory tract, as well as elsewhere in the body, and incorporate the targeting of these proteases as therapeutic drugs for use in humans. Host cell proteases are also linked to the systemic spread of viruses and play important roles outside of the respiratory tract; therefore, we address how proteases affect viruses across the spectrum of infections that can occur in humans, intending to understand the extrapulmonary spread of SARS-CoV-2.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
