Version 1
: Received: 15 April 2024 / Approved: 15 April 2024 / Online: 16 April 2024 (11:02:57 CEST)
Version 2
: Received: 27 April 2024 / Approved: 28 April 2024 / Online: 29 April 2024 (04:39:44 CEST)
Xiao, D.; Wang, Y.; Gao, C.; Zhang, X.; Feng, W.; Lu, X.; Feng, B. A New Quinazolinone Alkaloid along with Known Compounds with Seed-Germination-Promoting Activity from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6. Molecules2024, 29, 2112.
Xiao, D.; Wang, Y.; Gao, C.; Zhang, X.; Feng, W.; Lu, X.; Feng, B. A New Quinazolinone Alkaloid along with Known Compounds with Seed-Germination-Promoting Activity from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6. Molecules 2024, 29, 2112.
Xiao, D.; Wang, Y.; Gao, C.; Zhang, X.; Feng, W.; Lu, X.; Feng, B. A New Quinazolinone Alkaloid along with Known Compounds with Seed-Germination-Promoting Activity from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6. Molecules2024, 29, 2112.
Xiao, D.; Wang, Y.; Gao, C.; Zhang, X.; Feng, W.; Lu, X.; Feng, B. A New Quinazolinone Alkaloid along with Known Compounds with Seed-Germination-Promoting Activity from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6. Molecules 2024, 29, 2112.
Abstract
A new quinazolinone alkaloid, named peniquinazolinone A (1), as well as eleven known compounds, 2-(2-hydroxy-3-phenylpropionamido)-N-methylbenzamide (2), viridicatin (3), viridicatol (4), (±)-cyclopeptin (5a/5b), dehydrocyclopeptin (6), cyclopenin (7), cyclopenol (8), methyl-indole-3-carboxylate (9), 2,5-dihydroxyphenyl acetate (10), methyl m-hydroxyphenylacetate (11), conidiogenone B (12), was isolated from the endophytic Penicillium sp. HJT-A-6 derived from the stem of Rhodiola tibetica. The chemical structures of all compounds were elucidated by comprehensive spectroscopic analysis, including 1D, 2D NMR and HRESIMS. The absolute configuration at C-13 of peniquinazolinone A (1) was established by applying the modified Mosher’s method. Compounds 2, 3, and 7 exhibited an optimal promoting effect on the seed germination of Rhodiola tibetica at a concentration of 0.01 mg/mL, while the optimal concentration for compounds 4 and 9 to promote Rhodiola tibetica seed germination is 0.001 mg/mL. Compound 12 showed optimal seed-germination-promoting activity at a concentration of 0.01 mg/mL. Compared with the positive drug 6-benzyladenine (6-BA), compounds 2, 3, 4, 7, 9, and 12 could extend the seed-germination period of Rhodiola tibetica up to the 11th day.
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