Bhattacharyya, S.; O-Sullivan, I.; Tobacman, J.K. N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B) Regulates PD-L1 Expression in Melanoma by an HDAC3-Mediated Epigenetic Mechanism. Int. J. Mol. Sci.2024, 25, 5851.
Bhattacharyya, S.; O-Sullivan, I.; Tobacman, J.K. N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B) Regulates PD-L1 Expression in Melanoma by an HDAC3-Mediated Epigenetic Mechanism. Int. J. Mol. Sci. 2024, 25, 5851.
Bhattacharyya, S.; O-Sullivan, I.; Tobacman, J.K. N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B) Regulates PD-L1 Expression in Melanoma by an HDAC3-Mediated Epigenetic Mechanism. Int. J. Mol. Sci.2024, 25, 5851.
Bhattacharyya, S.; O-Sullivan, I.; Tobacman, J.K. N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B) Regulates PD-L1 Expression in Melanoma by an HDAC3-Mediated Epigenetic Mechanism. Int. J. Mol. Sci. 2024, 25, 5851.
Abstract
Effects of the enzyme N-acetylgalactosamine-4-sulfatase (Arylsulfatase B, ARSB), which removes the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate, on the expression of PD-L1 were determined and the underlying mechanism of PD-L1 expression elucidated. Initial experiments in human melanoma cells (A375) showed PD-L1 expression increased from 357 ± 31 to 796 ± 50 pg/mg protein (p
Biology and Life Sciences, Biochemistry and Molecular Biology
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