Formenti, P.; Umbrello, M.; Pignataro, M.; Sabbatini, G.; Dottorini, L.; Gotti, M.; Brenna, G.; Menozzi, A.; Terranova, G.; Galimberti, A.; Pezzi, A. Managing Severe Cancer Pain with Oxycodone/Naloxone Treatment: A Literature Review Update. J. Pers. Med.2024, 14, 483.
Formenti, P.; Umbrello, M.; Pignataro, M.; Sabbatini, G.; Dottorini, L.; Gotti, M.; Brenna, G.; Menozzi, A.; Terranova, G.; Galimberti, A.; Pezzi, A. Managing Severe Cancer Pain with Oxycodone/Naloxone Treatment: A Literature Review Update. J. Pers. Med. 2024, 14, 483.
Formenti, P.; Umbrello, M.; Pignataro, M.; Sabbatini, G.; Dottorini, L.; Gotti, M.; Brenna, G.; Menozzi, A.; Terranova, G.; Galimberti, A.; Pezzi, A. Managing Severe Cancer Pain with Oxycodone/Naloxone Treatment: A Literature Review Update. J. Pers. Med.2024, 14, 483.
Formenti, P.; Umbrello, M.; Pignataro, M.; Sabbatini, G.; Dottorini, L.; Gotti, M.; Brenna, G.; Menozzi, A.; Terranova, G.; Galimberti, A.; Pezzi, A. Managing Severe Cancer Pain with Oxycodone/Naloxone Treatment: A Literature Review Update. J. Pers. Med. 2024, 14, 483.
Abstract
Severe cancer pain significantly diminishes patients' quality of life, leading to increased reliance on caregivers. Although opioid analgesics are effective, they may induce opioid-induced bowel dysfunction (OIBD) with symptoms such as nausea, vomiting, drowsiness, and constipation. While controlled-release oxycodone is a viable option, its prolonged use can lead to opi-oid-induced constipation (OIC). Addressing this, a relative novel formulation - a fixed 2:1 ratio of oxycodone and naloxone in prolonged release - aims to provide analgesia while alleviating OIC. This review critically assesses the evidence on the efficacy, safety, and patient experience of ox-ycodone/naloxone prolonged release in managing severe cancer pain, emphasizing the necessity for a targeted approach in this patient population.
Keywords
severe cancer pain; oxycodone/naloxone; pain management
Subject
Medicine and Pharmacology, Anesthesiology and Pain Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
