Chen, S. L., Hu, S. W., Lin, Y. Y., Liao, W. L., & Yang, J. J. (2024). Boehmeria Nivea Extract (BNE-RRC) Reverses Epithelial-Mesenchymal Transition and Inhibits Anchorage-Independent Growth in Tumor Cells. Preprints. https://doi.org/10.20944/preprints202403.1105.v1
Chicago/Turabian Style
Chen, S., Wen-Li Liao and Jaw-Ji Yang. 2024 "Boehmeria Nivea Extract (BNE-RRC) Reverses Epithelial-Mesenchymal Transition and Inhibits Anchorage-Independent Growth in Tumor Cells" Preprints. https://doi.org/10.20944/preprints202403.1105.v1
Abstract
The Epithelial-Mesenchymal-Transition (EMT) phenotype, identified as a significant clinical indicator in cancer, manifests as a biological process where cells transition from epithelial to mesenchymal characteristics. Physiologically, EMT plays a crucial role in tissue remodeling, promoting healing, repair, and responding to various tissue damages. This study investigates the impact of BNE-RRC on oral cancer cells (KB) and reveals its significant effects on cancer cell growth, migration, invasion, and EMT. BNE-RRC induces the epithelial-like morphology in KB cells, effectively reversing EMT to Mesenchymal-Epithelial Transition (MET). Extraordinarily, sustained culture of cancer cells with BNE-RRC for 14 days maintains an epithelial status even after treatment withdrawal, suggesting BNE-RRC as a potential therapeutic agent for cancer. These findings highligh the promise of BNE-RRC as a comprehensive therapeutic agent in cancer treatment by inhibiting cancer cell growth, migration, and invasion, while also orchestrating a reversal of the EMT process. The study proposes that BNE-RRC could be effective agent for cancer treatment.
Keywords
Boehmeria Nivea Extract (BNE-RRC); Epithelial-Mesenchymal Transition (EMT); Mesenchymal-Epithelial Transition (MET); Anchorage-Independent Growth; Telomerase Activity, and Reversal of EMT
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
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