Version 1
: Received: 5 March 2024 / Approved: 5 March 2024 / Online: 5 March 2024 (12:44:31 CET)
Version 2
: Received: 2 April 2024 / Approved: 2 April 2024 / Online: 3 April 2024 (16:38:00 CEST)
How to cite:
Chen, L. W.; Chen, G. J.; Gai, T. T.; Zhou, X. H.; Zhu, J. C.; Wang, R. Y.; Wang, X. M.; Guo, Y. J.; Wang, Y.; Xie, Z. W. L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed C. elegans. Preprints2024, 2024030267. https://doi.org/10.20944/preprints202403.0267.v2
Chen, L. W.; Chen, G. J.; Gai, T. T.; Zhou, X. H.; Zhu, J. C.; Wang, R. Y.; Wang, X. M.; Guo, Y. J.; Wang, Y.; Xie, Z. W. L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed C. elegans. Preprints 2024, 2024030267. https://doi.org/10.20944/preprints202403.0267.v2
Chen, L. W.; Chen, G. J.; Gai, T. T.; Zhou, X. H.; Zhu, J. C.; Wang, R. Y.; Wang, X. M.; Guo, Y. J.; Wang, Y.; Xie, Z. W. L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed C. elegans. Preprints2024, 2024030267. https://doi.org/10.20944/preprints202403.0267.v2
APA Style
Chen, L. W., Chen, G. J., Gai, T. T., Zhou, X. H., Zhu, J. C., Wang, R. Y., Wang, X. M., Guo, Y. J., Wang, Y., & Xie, Z. W. (2024). L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed <em>C. elegans</em>. Preprints. https://doi.org/10.20944/preprints202403.0267.v2
Chicago/Turabian Style
Chen, L. W., Yun Wang and Zhong wen Xie. 2024 "L-theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in UVC Exposed <em>C. elegans</em>" Preprints. https://doi.org/10.20944/preprints202403.0267.v2
Abstract
L-Theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effect, regulation of immune response, relaxing neural tension, reducing oxidative damage. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) in UVC-exposed nematodes. In addition, L-theanine treatment also up-regulated the expression of genes related to mitochondrial energy metabolism in UVC-exposed nematodes. Our study provided a theoretical basis for the possibility that tea drinking may prevent mitochondrial related diseases.
Keywords
L-theanine; UVC; mitochondrial DNA damage; C. elegans; lifespan
Subject
Medicine and Pharmacology, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.