Cho, H.; Hong, N.-K.; Yong, I.; Kwon, H.-Y.; Kang, N.-Y.; Ciaramicoli, L. M.; Kim, P.; Chang, Y.-T. Advanced-Glycation End Products-Selective Probe Development. Preprints2024, 2024021624. https://doi.org/10.20944/preprints202402.1624.v1
APA Style
Cho, H., Hong, N. K., Yong, I., Kwon, H. Y., Kang, N. Y., Ciaramicoli, L. M., Kim, P., & Chang, Y. T. (2024). Advanced-Glycation End Products-Selective Probe Development. Preprints. https://doi.org/10.20944/preprints202402.1624.v1
Chicago/Turabian Style
Cho, H., Pilnam Kim and Young-Tae Chang. 2024 "Advanced-Glycation End Products-Selective Probe Development" Preprints. https://doi.org/10.20944/preprints202402.1624.v1
Abstract
Advanced glycation end products (AGEs) play a significant role in the aging processes, further regarding as a hallmark of aging. Despite the importance, a lack of monitoring tools has hampered the study of relationship between AGEs and aging. Here, we firstly report a novel AGEs-selective probe, AGO. AGO presented its ability to detect AGEs more sensitively than a conventional approach of measuring autofluorescence from AGEs. In addition, we confirmed that AGO can detect AGEs depending on kinetics, reflecting by a preference to ribose-derived AGEs. Finally, AGO revealed its competence to visualize glycation products in glycation mimicking model, made by collagen framework. We believe that this study will enrich molecular toolboxes to understand physiological processes of AGEs during aging processes.
Keywords
Advanced glycation products; fluorescence small molecule; Fluorescence library; Screening; Aging
Subject
Chemistry and Materials Science, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.