Chisavu, L.; Ivan, V.M.; Mihaescu, A.; Chisavu, F.; Schiller, O.; Marc, L.; Bob, F.; Schiller, A. Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study. Diagnostics2024, 14, 664.
Chisavu, L.; Ivan, V.M.; Mihaescu, A.; Chisavu, F.; Schiller, O.; Marc, L.; Bob, F.; Schiller, A. Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study. Diagnostics 2024, 14, 664.
Chisavu, L.; Ivan, V.M.; Mihaescu, A.; Chisavu, F.; Schiller, O.; Marc, L.; Bob, F.; Schiller, A. Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study. Diagnostics2024, 14, 664.
Chisavu, L.; Ivan, V.M.; Mihaescu, A.; Chisavu, F.; Schiller, O.; Marc, L.; Bob, F.; Schiller, A. Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis—A Pilot Prospective Observational Cohort Study. Diagnostics 2024, 14, 664.
Abstract
Chronic kidney disease patients treated by hemodialysis present a high cardio-vascular morbidity and mortality. There is an imperative need for novel biomarkers in identifying and to offer possible therapeutically intervention in these patients. We performed a prospective observational cohort study on 77 patients in the period October 2021 – October 2023. We measured serum plasma levels of Interleukin 1-Beta, Galectin 3, human suppression of tumorigenicity factor 2, bone morphogenetic protein 2 and fibroblastic growth factor 23 at the inclusion. We evaluated the correlations of these biomarkers with cardiac function and structure evaluated by echocardiography. Mean age was 61.02 (±11.81) years, 45 (56.2%) males and with a dialysis vintage of 4.95 (2.4-7.8) years. Median ejection fraction was 51 (43-54 %) and more than two thirds of the patients presented valvular calcifications. Overall mortality was 22%. Interleukin 1-Beta correlated positively with ejection fraction and global longitudinal strain and negatively with left atrium diameter and left ventricle tele systolic diameter. Galectin 3 values negatively correlated with aortic valve fibrosis and mitral valve calcifications and human suppression tumorigenity factor 2 negatively correlated with mitral valve calcifications. Some of these novel biomarkers could be used to better asses the cardio-vascular disease in patients on maintenance hemodialysis.
Keywords
hemodialysis; mortality; cardio-vascular disease; novel biomarkers; cardiac function and structure
Subject
Medicine and Pharmacology, Internal Medicine
Copyright:
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