Review
Version 1
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Formulating Treatment to Cure Alzheimer’s Dementia
Version 1
: Received: 13 February 2024 / Approved: 14 February 2024 / Online: 14 February 2024 (13:44:16 CET)
A peer-reviewed article of this Preprint also exists.
Fessel, J. Formulating Treatment to Cure Alzheimer’s Dementia: Approach #2. Int. J. Mol. Sci. 2024, 25, 3524. Fessel, J. Formulating Treatment to Cure Alzheimer’s Dementia: Approach #2. Int. J. Mol. Sci. 2024, 25, 3524.
Abstract
There are two generic approaches to curing any medical condition. The first treats every patient for all of the known possible causes that contribute to pathogenesis; the second individualizes potentially curative therapy by identifying in each separate patient only those components of pathogenesis that are actually operative, and treating those. This article adopts the second approach for formulating a cure of Alzheimer’s dementia (AD).
Components of AD’s pathogenesis are, in alphabetical order: circadian rhythm disturbances, depression, diabetes and insulin resistance, dyslipidemia, hypertension, inflammation, metabolic syndrome, mitochondrial dysfunction, nutritional deficiencies, TGF-β deficiency, underweight, vascular abnormalities, and Wnt/β-catenin deficiency. For each component, data are described that show the degree by which its prevalence is more in the patients with mild cognitive impairment (MCI) who did not revert to having normal cognition than in those who did, because the former group is the pool of patients from among which future AD may develop. Addressing only those components that are present in a particular individual, is potentially a curative strategy. Published data indicate that curative therapy requires that the number of such components to address should be ≥3. Although structural brain changes cannot be directly addressed, the impaired neural tracts result from many of the reversible causal elements, so correcting them will benefit those tract
Keywords
Alzheimer's dementia; cure; causal elements; individualize therapy; treat elements applicable to individual
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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