Version 1
: Received: 11 January 2024 / Approved: 12 January 2024 / Online: 12 January 2024 (07:03:45 CET)
How to cite:
Alves, T. G. L.; Xavier, P. L. P.; Garnica, T. K.; Rochetti, A. L.; Vendramini, T. H. A.; Haddad, F.; Munir, M.; Brunetto, M. A.; Fukumasu, H. Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells. Preprints2024, 2024010983. https://doi.org/10.20944/preprints202401.0983.v1
Alves, T. G. L.; Xavier, P. L. P.; Garnica, T. K.; Rochetti, A. L.; Vendramini, T. H. A.; Haddad, F.; Munir, M.; Brunetto, M. A.; Fukumasu, H. Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells. Preprints 2024, 2024010983. https://doi.org/10.20944/preprints202401.0983.v1
Alves, T. G. L.; Xavier, P. L. P.; Garnica, T. K.; Rochetti, A. L.; Vendramini, T. H. A.; Haddad, F.; Munir, M.; Brunetto, M. A.; Fukumasu, H. Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells. Preprints2024, 2024010983. https://doi.org/10.20944/preprints202401.0983.v1
APA Style
Alves, T. G. L., Xavier, P. L. P., Garnica, T. K., Rochetti, A. L., Vendramini, T. H. A., Haddad, F., Munir, M., Brunetto, M. A., & Fukumasu, H. (2024). Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells. Preprints. https://doi.org/10.20944/preprints202401.0983.v1
Chicago/Turabian Style
Alves, T. G. L., Márcio Antonio Brunetto and Heidge Fukumasu. 2024 "Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells" Preprints. https://doi.org/10.20944/preprints202401.0983.v1
Abstract
Lymphoma is the most prevalent type of cancer in cats, and the search for alternative treatments is of utmost importance given the significant number of animals that exhibit tumor recurrence or are unresponsive to conventional chemotherapy treatment. Oncolytic viruses possess a unique ability to target and eliminate cancer cells while simultaneously stimulating an immune response against these malignant cells. The present study aimed to explore the oncolytic potential of Newcastle Disease Virus expressing green fluorescent protein (NDV-GFP) in a feline leukemia virus (FeLV)-positive lymphoma cell line. Our research suggests that NDV-GFP has a propensity to selectively target, infiltrate, and replicate with-in feline lymphoma cells, resulting in the induction of apoptosis in these cells, as opposed to non-tumor cells. Therefore, our research provides evidence supporting the development of novel oncolytic therapies based on NDV for the treatment of feline lymphomas.
Keywords
cat; virotherapy; oncolytic Newcastle Disease Virus; new therapies; cancer; lentogenic; in vitro; immunotherapy
Subject
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.