Magnani, L.; Aguglia, A.; Alexander, J.; Maiorano, A.; Richard-Lepouriel, H.; Iancau, S.P.; Amerio, A.; Parise, A.; Serafini, G.; Amore, M.; Nguyen, K.D.; Costanza, A. Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors—A Narrative Review. Brain Sci.2024, 14, 30.
Magnani, L.; Aguglia, A.; Alexander, J.; Maiorano, A.; Richard-Lepouriel, H.; Iancau, S.P.; Amerio, A.; Parise, A.; Serafini, G.; Amore, M.; Nguyen, K.D.; Costanza, A. Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors—A Narrative Review. Brain Sci. 2024, 14, 30.
Magnani, L.; Aguglia, A.; Alexander, J.; Maiorano, A.; Richard-Lepouriel, H.; Iancau, S.P.; Amerio, A.; Parise, A.; Serafini, G.; Amore, M.; Nguyen, K.D.; Costanza, A. Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors—A Narrative Review. Brain Sci.2024, 14, 30.
Magnani, L.; Aguglia, A.; Alexander, J.; Maiorano, A.; Richard-Lepouriel, H.; Iancau, S.P.; Amerio, A.; Parise, A.; Serafini, G.; Amore, M.; Nguyen, K.D.; Costanza, A. Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors—A Narrative Review. Brain Sci. 2024, 14, 30.
Abstract
Abstract: Background: chronotype is generally defined as the variability of the phase angle of en-trainment, while the latter reflects the relationship between the timing of a certain rhythm (e.g., sleep-wake cycle) and the timing of an external temporal cue. Individuals can be placed on a spectrum from "morning types" (M types), to "evening types" (E types). E-chronotype has been proposed as a transdiagnostic risk factor for psychiatric conditions and associated with psycho-pathological dimensions. Eveningness seems correlated with both suicidal ideation (SI) and suicidal behavioral (SB), through several possible mediating factors. Immunological alterations also have been linked to later chronotypes and SI/SB. Objective: This narrative review aims to summarize the evidence supporting the possible association between chronotypes and suicide, with the eventual mediating role of neuroinflammation and several psychopathological dimensions. Material and methods: A search of literature (2003-2023) was conducted, using various databases: PUBMED, EMBASE, Scopus, UpToDate, PsycINFO, Cochrane Library. English-language articles were col-lected and screened for eligibility. Results: Despite the apparent absence of a direct correlation between E-chronotype and suicidality, E-chronotype promotes a chain of effects that could be in-volved in an increased risk of SB, in which with neuroinflammation possibly play an intriguing role and some psychopathological dimensions may stand out.
Medicine and Pharmacology, Psychiatry and Mental Health
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