Review
Version 1
Preserved in Portico This version is not peer-reviewed
The Role of Non-Coding RNAs in Myelodysplastic Neoplasms
Version 1
: Received: 28 August 2023 / Approved: 28 August 2023 / Online: 29 August 2023 (13:42:14 CEST)
A peer-reviewed article of this Preprint also exists.
Georgoulis, V.; Koumpis, E.; Hatzimichael, E. The Role of Non-Coding RNAs in Myelodysplastic Neoplasms. Cancers 2023, 15, 4810. Georgoulis, V.; Koumpis, E.; Hatzimichael, E. The Role of Non-Coding RNAs in Myelodysplastic Neoplasms. Cancers 2023, 15, 4810.
Abstract
Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia and an increased risk for evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review will present a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.
Keywords
myelodysplastic syndromes; non-coding RNA; microRNA; lnc-RNA; circ-RNA; piwi-RNA; t-RNA; sno-RNA
Subject
Medicine and Pharmacology, Hematology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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