Version 1
: Received: 22 June 2023 / Approved: 23 June 2023 / Online: 23 June 2023 (11:55:35 CEST)
Version 2
: Received: 5 July 2023 / Approved: 10 July 2023 / Online: 10 July 2023 (14:23:12 CEST)
How to cite:
Radwan, M.; Abd-Alla, H. I.; Elmezayen, H.; Abourehab, M. A.; El‐Beeh, M. E.; Tateishi, H.; Otsuka, M.; Fujita, M. Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review. Preprints2023, 2023061671. https://doi.org/10.20944/preprints202306.1671.v2
Radwan, M.; Abd-Alla, H. I.; Elmezayen, H.; Abourehab, M. A.; El‐Beeh, M. E.; Tateishi, H.; Otsuka, M.; Fujita, M. Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review. Preprints 2023, 2023061671. https://doi.org/10.20944/preprints202306.1671.v2
Radwan, M.; Abd-Alla, H. I.; Elmezayen, H.; Abourehab, M. A.; El‐Beeh, M. E.; Tateishi, H.; Otsuka, M.; Fujita, M. Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review. Preprints2023, 2023061671. https://doi.org/10.20944/preprints202306.1671.v2
APA Style
Radwan, M., Abd-Alla, H. I., Elmezayen, H., Abourehab, M. A., El‐Beeh, M. E., Tateishi, H., Otsuka, M., & Fujita, M. (2023). Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review. Preprints. https://doi.org/10.20944/preprints202306.1671.v2
Chicago/Turabian Style
Radwan, M., Masami Otsuka and Mikako Fujita. 2023 "Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review" Preprints. https://doi.org/10.20944/preprints202306.1671.v2
Abstract
Abstract: In the last decade, gypsogenin has widely grabbed the attention of medicinal chemists by virtue of its prominent anti-cancer potential. Despite its late identification, gypsogenin proved itself as a new an-ti-proliferative player battling for a front position among other classic pentacyclic triterpenes such as oleanolic acid, glycyrrhetinic acid, ursolic acid, betulinic acid, and celastrol. Herein, we present insights into the anti-cancer activity of gypsogenin and its semisynthetic derivatives and go further by introducing our perspective to judiciously guide the prospect rational design. The present article opens a new venue for better exploitation of gypsogenin chemical entity as a lead compound in cancer chemotherapy. To the best of our knowledge, this is the first review article exploring the anti-cancer activity of gypsogenin derivatives.
Keywords
pentacyclic triterpenes; gypsogenin; anti-cancer
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Mohamed Radwan
Commenter's Conflict of Interests: Author