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Analysis of Corticosteroid-Induced Glaucoma Using the Japanese Adverse Drug Event Reporting Database
Version 1
: Received: 29 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (11:43:13 CEST)
A peer-reviewed article of this Preprint also exists.
Kawabe, A.; Uesawa, Y. Analysis of Corticosteroid-Induced Glaucoma Using the Japanese Adverse Drug Event Reporting Database. Pharmaceuticals 2023, 16, 948. Kawabe, A.; Uesawa, Y. Analysis of Corticosteroid-Induced Glaucoma Using the Japanese Adverse Drug Event Reporting Database. Pharmaceuticals 2023, 16, 948.
Abstract
: Glaucoma is the most common cause of blindness, which significantly reduces quality of life. Most glaucoma cases are primary glaucoma; nevertheless, many patients suffer from glaucoma caused by drugs, such as corticosteroids. A comprehensive review of the risks associated with corticosteroid-induced glaucoma is limited. Therefore, we used the Japanese Adverse Drug Event Reporting Database (JADER) published by the Pharmaceuticals and Medical Devices Agency (PMDA) to analyze the risk factors associated with glaucoma and the trends and characteristics of corticosteroid-induced glaucoma. We did not find sex or age differences associated with the onset of glaucoma. Hierarchical clustering and principal component analysis revealed that triamcinolone acetonide and betamethasone sodium phosphate, which are used around the eyes in Japan, are more likely to induce intraocular pressure (IOP) elevation compared with other corticosteroids. Increased IOP is a direct cause of glaucoma. Based on these findings, it may be necessary to limit or avoid the use of these corticosteroids.
Keywords
glaucoma; corticosteroids; intraocular pressure; Japanese Adverse Drug Event Report; spontaneous reporting system; volcano plot; hierarchical clustering; principal component analysis
Subject
Medicine and Pharmacology, Ophthalmology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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