Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Anti-inflammatory Activity of Sanghuangporus sanghuang Mycelium

Version 1 : Received: 7 December 2016 / Approved: 7 December 2016 / Online: 7 December 2016 (11:15:30 CET)

A peer-reviewed article of this Preprint also exists.

Lin, W.-C.; Deng, J.-S.; Huang, S.-S.; Wu, S.-H.; Chen, C.-C.; Lin, W.-R.; Lin, H.-Y.; Huang, G.-J. Anti-Inflammatory Activity of Sanghuangporus sanghuang Mycelium. Int. J. Mol. Sci. 2017, 18, 347. Lin, W.-C.; Deng, J.-S.; Huang, S.-S.; Wu, S.-H.; Chen, C.-C.; Lin, W.-R.; Lin, H.-Y.; Huang, G.-J. Anti-Inflammatory Activity of Sanghuangporus sanghuang Mycelium. Int. J. Mol. Sci. 2017, 18, 347.

Abstract

Acute lung injury (ALI) is characterized by inflammation of the lung tissue and oxidative injury caused by excessive accumulation of reactive oxygen species. Studies have suggested that anti-inflammatory or antioxidant agents could be used for the treatment of ALI with a good outcome. Therefore, our study aimed to test whether the mycelium extract of Sanghuangporus sanghuang (SS-1), believed to exhibit antioxidant and anti-inflammatory properties, could be used against the excessive inflammatory response associated with LPS-induced ALI in mice and to investigate its possible mechanism of action. The experimental results showed that the administration of SS-1 could inhibit LPS-induced inflammation. SS-1 could reduce the number of inflammatory cells, inhibit MPO activity, regulate the TLR4/PI3K/Akt/mTOR pathway and the signal transduction of NF-κB and MAPK pathways in the lung tissue, and inhibit HNGB1 activity in BALF. In addition, SS-1 could affect the synthesis of antioxidant enzymes HO-1 and Trx-1 in the lung tissue and regulate signal transduction in the KAP1/Nrf2/Keap1 pathway. Histological results showed that administration of SS-1 prior to induction could inhibit the large-scale LPS-induced neutrophil infiltration of the lung tissue. Therefore, based on all experimental results, we propose that SS-1 exhibits a protective effect against LPS-induced (ALI) in mice. The mycelium of S. sanghuang can potentially be used for the treatment or prevention of inflammation-related diseases

Keywords

acute lung injury; mycelium of Sanghuangporus sanghuang; lipopolysaccharide; KAP1/Nrf2 pathway; PI3K/Akt/mTOR pathways; HO-1; HNGB1

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

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