Preprint Article Version 1 NOT YET PEER-REVIEWED

Transmural Cellular Heterogeneity in Myocardial Electromechanics

  1. Ural Federal University, Ekaterinburg 620002, Russia
  2. Institute of Immunology and Physiology, Russian Academy of Sciences, Ekaterinburg 620049, Russia
  3. Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-0082, Japan
  4. Institute of Mathematics and Mechanics, Russian Academy of Sciences, Ekaterinburg 620049, Russia
Version 1 : Received: 1 November 2016 / Approved: 2 November 2016 / Online: 2 November 2016 (06:58:53 CET)

How to cite: Khokhlova, A.; Vikulova, N.; Katsnelson, L.; Iribe, G.; Solovyova, O. Transmural Cellular Heterogeneity in Myocardial Electromechanics. Preprints 2016, 2016110015 (doi: 10.20944/preprints201611.0015.v1). Khokhlova, A.; Vikulova, N.; Katsnelson, L.; Iribe, G.; Solovyova, O. Transmural Cellular Heterogeneity in Myocardial Electromechanics. Preprints 2016, 2016110015 (doi: 10.20944/preprints201611.0015.v1).

Abstract

Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the action potential and contraction of the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes via cooperative mechanisms of mechano-calcium-electric feedback are essential to produce the differences in Ca2+ transients and contraction profiles and may further enhance transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in afterload than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart.

Subject Areas

cardiac transmural heterogeneity; electromechanical coupling; mechano-calcium-electric feedback; cardiac modeling; cardiomyocyte

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