Preprint Review Version 1 NOT YET PEER-REVIEWED

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

  1. Department of Bioengineering, University of Pittsburgh, Pittsburgh, 15260 PA, USA
  2. Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, 15260 PA, USA
  3. Division of Cardiology, Allegheny General Hospital, Pittsburgh, 15212 PA, USA
  4. Bone and Joint Center at Magee-Women’s Hospital of UPMC, Pittsburgh, 15213 PA, USA
  5. Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, 15260 PA, USA
  6. McGowan Insititute for Regenerative Medicine, Pittsburgh, 15219 PA, USA
  7. Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, 15260 PA, USA
  8. Division of Vascular Surgery, University of Pittsburgh Medical Center, Pittsburgh, 15213 PA, USA
Version 1 : Received: 23 September 2016 / Approved: 26 September 2016 / Online: 26 September 2016 (10:34:26 CEST)

A peer-reviewed article of this Preprint also exists.

Shridhar, P.; Chen, Y.; Khalil, R.; Plakseychuk, A.; Cho, S.K.; Tillman, B.; Kumta, P.N.; Chun, Y. A Review of PMMA Bone Cement and Intra‐Cardiac Embolism. Materials 2016, 9, 821. Shridhar, P.; Chen, Y.; Khalil, R.; Plakseychuk, A.; Cho, S.K.; Tillman, B.; Kumta, P.N.; Chun, Y. A Review of PMMA Bone Cement and Intra‐Cardiac Embolism. Materials 2016, 9, 821.

Journal reference: Materials 2016, 9, 821
DOI: 10.3390/ma9100821

Abstract

Percutaneous vertebroplasty procedure is of major importance, given the significant increasing aging population and higher number of orthopedic procedures related to vertebral compression fractures. Vertebroplasty is a complex technique involving injection of polymethylmethacrylate (PMMA) into the compressed vertebral body for mechanical stabilization of the fracture. Our understanding and ability to modify these mechanisms through alterations in cement material is rapidly evolving. However, the rate of cardiac complications secondary to PMMA injection and subsequent cement leakage has increased with time. The following review considers the main features of PMMA bone cement on the heart, and the extent of influence of materials on cardiac embolism. Clinically, cement leakage results in life-threatening cardiac injury. The convolution of this outcome through an appropriate balance of complex material properties is highlighted via clinical case report.

Subject Areas

PMMA; bone cement; cardiac embolism; cement leakage; viscosity

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