Preprint Article Version 1 NOT YET PEER-REVIEWED

Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis

  1. Biological Product Lab, Department of Botany, University of Allahabad, Allahabad 211012, U.P., India
  2. Lichenology Laboratory, CSIR-National Botanical Research Institute, Rana Pratap Marg, Lucknow 226001, U.P., India
Version 1 : Received: 8 September 2016 / Approved: 9 September 2016 / Online: 9 September 2016 (07:44:48 CEST)

A peer-reviewed article of this Preprint also exists.

Pathak, A.; Upreti, D.K.; Dikshit, A. Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis. Medicines 2016, 3, 24. Pathak, A.; Upreti, D.K.; Dikshit, A. Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis. Medicines 2016, 3, 24.

Journal reference: Medicines 2016, 3, 24
DOI: 10.3390/medicines3030024

Abstract

In the present study, the new biological sources in the form of lichen Usnea orientalis Motyka was screened for its antidermatophytic potential. Six species of dermatophytes were chosen on the basis of their prevalence for antidermatophytic assays, and the Clinical Laboratory Standard Institute (CLSI)-recommended broth microdilution procedure was used to detect the efficacy of extract against dermatophytes. Thin layer chromatography of lichen extracts reveals the presence of two secondary metabolites viz. salazinic acid and usnic acid. U. orientalis extract exhibited promising antidermatophytic activity against all tested pathogens. Amongst all tested pathogens, E. floccosum exhibited most susceptibility towards extract, whereas T. mentagrophytes exhibited the least susceptibility. Topical application of U. orientalis extract might be helpful in the cure of dermal infections.

Subject Areas

antidermatophytic; dermatophytes; DPPH; Lichen

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