Preprint Article Version 1 NOT YET PEER-REVIEWED

Preparation and Biomimetic Surface Modification of Doped Cerium Oxide Nanoparticles Promising for Bio-Imaging and Therapeutics

  1. Physical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
  2. School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
Version 1 : Received: 2 September 2016 / Approved: 3 September 2016 / Online: 3 September 2016 (11:16:56 CEST)

How to cite: Nanda, H. Preparation and Biomimetic Surface Modification of Doped Cerium Oxide Nanoparticles Promising for Bio-Imaging and Therapeutics. Preprints 2016, 2016090008 (doi: 10.20944/preprints201609.0008.v1). Nanda, H. Preparation and Biomimetic Surface Modification of Doped Cerium Oxide Nanoparticles Promising for Bio-Imaging and Therapeutics. Preprints 2016, 2016090008 (doi: 10.20944/preprints201609.0008.v1).

Abstract

The biomimetic surface modification of metal oxide nanoparticles has been used as an important tool in nanomedicine application. In this report, we have used the concept of biomimetic surface modification for the preparation of aqueous dispersible, trivalent metal ion (samarium)-doped, redox altered cerium oxide nanoparticles (SmCNPs) of biological relevance. SmCNP surface modified with hydrophilic biocompatible (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane (MEEETES) were prepared using ammonia induced ethylene glycol assisted precipitation method and were characterized using complementary characterization techniques. The chemical interaction of functional moieties to the nanoparticle surface was studied using powerful 13C cross polarization magic angle sample spinning nuclear magnetic resonance spectroscopy. The results demonstrated the production of the extremely small size MEEETES surface modified doped nanoparticles with significant reduction in aggregation compared to their unmodified state. Moreover, the functional moieties had covalent interaction with the surface of nanoparticles. The concept of biomimetic surface modification using MEEETES should also be extended to several other transition metal ion doped and co-doped CNPs for the production of aqueous dispersible redox altered CNPs promising for bio-imaging and therapeutic applications.

Subject Areas

cerium oxide nanoparticle; doped and co-doped; biomimetic; covalent surface modification; aqueous dispersible; nanobiological applications

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