Preprint Article Version 1 NOT YET PEER-REVIEWED

Covalent Surface Modification of Cerium Oxide Nanoparticles Promising for Nanomedicine Application

  1. Physical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
  2. Present Address: School of Materials Science and Engineering, Nanyang Technological University,50 Nanyang Avenue, Singapore 639798, Singapore
Version 1 : Received: 10 August 2016 / Approved: 10 August 2016 / Online: 10 August 2016 (15:05:47 CEST)

How to cite: Nanda, H. Covalent Surface Modification of Cerium Oxide Nanoparticles Promising for Nanomedicine Application. Preprints 2016, 2016080112 (doi: 10.20944/preprints201608.0112.v1). Nanda, H. Covalent Surface Modification of Cerium Oxide Nanoparticles Promising for Nanomedicine Application. Preprints 2016, 2016080112 (doi: 10.20944/preprints201608.0112.v1).

Abstract

Cerium Oxide Nanoparticles (CNPs) have been emerged as a potential nanomedicine for treatment of several diseases including cancer. CNPs have the natural tendency to aggregate or agglomerate at its bare state and led to sedimentation at biological environment. Since the biological environment is essentially aqueous, nanoparticle surface modification using suitable biocompatible hydrophilic chemical moiety is highly desirable for its stable aqueous dispersion. In this report, we have used (6-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane to engineer the CNP’s surface for production of improved grade nanoparticles for potential nano-biological application. The surface modified nanoparticles were produced by ammonia-induced ethylene glycol assisted precipitation method and were characterized using high resolution transmission electron microscopy, powdered x-ray diffraction analysis and dynamic light scattering techniques. The interaction of functional moiety with the surface of nanoparticle was studied using powerful cross polarization magic angle sample spinning solid state nuclear magnetic resonance spectroscopy. The prepared nanoparticles demonstrated improved aqueous dispersibility and more importantly a covalent interaction among the functional moiety and the surface of the nanoparticle. The surface modified nanoparticles should be promising for nanomedicine applications.

Subject Areas

Cerium Oxide nanoparticle; covalent surface modification; aqueous dispersion; nanomedicine

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