School of Pharmacy, University of Camerino, Camerino 62032, Italy
Department of Clinical Sciences, Section of Biochemistry, Polytechnic University of Marche, Ancona 60121, Italy
Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden
Laboratory of Medicinal Plant Biochemistry, Food Science and Nutrition, Department of Biochemistry, Faculty of Sciences, University of Dschang, BP 96 Dschang, Cameroon
School of Biosciences and Veterinary Medicine, University of Camerino, Camerino 62032, Italy
: Received: 10 August 2016 / Approved: 10 August 2016 / Online: 10 August 2016 (12:36:57 CEST)
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How to cite:
Petrelli, R.; Orsomando, G.; Sorci, L.; Maggi, F.; Ranjbarian, F.; Biapa Nya, P.; Petrelli, D.; Vitali, L.; Lupidi, G.; Quassinti, L.; Bramucci, M.; Hofer, A.; Cappel, L. Biological Activities of the Essential Oil from Erigeron floribundus. Preprints2016, 2016080111 (doi: 10.20944/preprints201608.0111.v1).
Petrelli, R.; Orsomando, G.; Sorci, L.; Maggi, F.; Ranjbarian, F.; Biapa Nya, P.; Petrelli, D.; Vitali, L.; Lupidi, G.; Quassinti, L.; Bramucci, M.; Hofer, A.; Cappel, L. Biological Activities of the Essential Oil from Erigeron floribundus. Preprints 2016, 2016080111 (doi: 10.20944/preprints201608.0111.v1).
Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in the Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (IZD of 14 mm, MIC of 512 µg/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC50 of 98 µg/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC50 values of 33.5 µg/mL with the essential oil and 5.6 µg/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC50 value of 14.89 µg/mL, and remarkable ferric reducing antioxidant power (TEAC= 411.9 μmol TE/g).