Preprint Article Version 1 NOT YET PEER-REVIEWED

TPGS-Stabilized Curcumin Nanoparticles Exhibit Superior Effect on Carrageenan-Induced Inflammation in Wistar Rat

  1. Pharmaceutics Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia
  2. Research Center for Nanosciences and Nanotechnology, Bandung Institute of Technology, Bandung 40132, Indonesia
  3. Pharmacology and Clinical Pharmacy Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia
  4. University of Surabaya, Surabaya 60284, Indonesia
Version 1 : Received: 10 August 2016 / Approved: 10 August 2016 / Online: 10 August 2016 (12:08:30 CEST)
Version 2 : Received: 10 August 2016 / Approved: 11 August 2016 / Online: 11 August 2016 (11:24:03 CEST)

A peer-reviewed article of this Preprint also exists.

Rachmawati, H.; Safitri, D.; Pradana, A.T.; Adnyana, I.K. TPGS-Stabilized Curcumin Nanoparticles Exhibit Superior Effect on Carrageenan-Induced Inflammation inWistar Rat. Pharmaceutics 2016, 8, 24. Rachmawati, H.; Safitri, D.; Pradana, A.T.; Adnyana, I.K. TPGS-Stabilized Curcumin Nanoparticles Exhibit Superior Effect on Carrageenan-Induced Inflammation inWistar Rat. Pharmaceutics 2016, 8, 24.

Journal reference: Pharmaceutics 2016, 8, 24
DOI: 10.3390/pharmaceutics8030024

Abstract

Curcumin, a hydrophobic polyphenol compound derived from the rhizome of Curcuma genus has wide spectrum of biological and pharmacological activities. Previously, curcumin nanocrystal with different stabilizers had been produced successfully in order to enhance solubility and per oral absorption. In present study, we tested the anti-inflammatory effect of TPGS-stabilized curcumin nanocrystal in vivo. Lambda-carrageenan was used to induce inflammation in rat, given by intraplantar route and intrapelurally through surgery in the pleurisy test. In lambda-carrageenan-induced edema model, TPGS-stabilized curcumin nanocrystal was given orally 1 hour before induction and at 0.5, 4.5, and 8.5 hour after induction with 2 different doses (1.8 and 0.9 mg/kg BW). Sodium diclofenac with a dose of 4.5 mg/kg BW was used as a standard drug. Physical mixture of curcumin-TPGS was also used as a comparison with higher dose of 60 mg/kg BW. The anti-inflammatory effect was assessed on the edema in carrageenan-induced paw edema model and volume of exudate as well as number of leukocytes reduction in the pleurisy test. TPGS-stabilized curcumin nanocrystal with lower doses showed better anti-inflammatory effect, indicating the greater absorption capability through gastrointestinal tract.

Subject Areas

curcumin; nanoparticle; inflammation; λ-carrageenan; nanoparticle permeability; Biopharmaceutical Class System (BCS) 4

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