Preprint Review Version 1 NOT YET PEER-REVIEWED

Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction

1
Institute of Biotechnology, University of Helsinki, 00100 Helsinki, Finland
2
Finnish Institute of Occupational Health, Helsinki, Finland
3
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00100 Helsinki, Finland
4
Institute of Mathematics and Computer Science, Ural Federal University, Yekaterinburg, Sverdlovsk Oblast, Russia
5
Q-Mol L.L.C., San Diego, CA, USA
6
Department of Mathematics and Statistics, University of Turku, Turku, Finland
7
Institute of Clinical Medicine, Sognsvannsveien 20, Rikshospitalet, 0372 Oslo, Norway
8
Department of Rheumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Version 1 : Received: 5 August 2016 / Approved: 5 August 2016 / Online: 5 August 2016 (12:41:07 CEST)

A peer-reviewed article of this Preprint also exists.

Söderholm, S.; Fu, Y.; Gaelings, L.; Belanov, S.; Yetukuri, L.; Berlinkov, M.; Cheltsov, A.V.; Anders, S.; Aittokallio, T.; Nyman, T.A.; Matikainen, S.; Kainov, D.E. Multi-Omics Studies towards Novel Modulators of Influenza A Virus–Host Interaction. Viruses 2016, 8, 269. Söderholm, S.; Fu, Y.; Gaelings, L.; Belanov, S.; Yetukuri, L.; Berlinkov, M.; Cheltsov, A.V.; Anders, S.; Aittokallio, T.; Nyman, T.A.; Matikainen, S.; Kainov, D.E. Multi-Omics Studies towards Novel Modulators of Influenza A Virus–Host Interaction. Viruses 2016, 8, 269.

Journal reference: Viruses 2016, 8, 269
DOI: 10.3390/v8100269

Abstract

Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 200 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the remaining 665 is unknown. Studying anti-influenza efficacy, immuno-modulating properties and potential resistance of these compounds or their combinations may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics.

Subject Areas

influenza virus; antiviral agent; proteomics; phosphoproteomics; metabolomics; transcriptomics; genomics; virtual ligand screening

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