Preprint Review Version 1 NOT YET PEER-REVIEWED

Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction

  1. Institute of Biotechnology, University of Helsinki, 00100 Helsinki, Finland
  2. Finnish Institute of Occupational Health, Helsinki, Finland
  3. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00100 Helsinki, Finland
  4. Institute of Mathematics and Computer Science, Ural Federal University, Yekaterinburg, Sverdlovsk Oblast, Russia
  5. Q-Mol L.L.C., San Diego, CA, USA
  6. Department of Mathematics and Statistics, University of Turku, Turku, Finland
  7. Institute of Clinical Medicine, Sognsvannsveien 20, Rikshospitalet, 0372 Oslo, Norway
  8. Department of Rheumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Version 1 : Received: 5 August 2016 / Approved: 5 August 2016 / Online: 5 August 2016 (12:41:07 CEST)

A peer-reviewed article of this Preprint also exists.

Söderholm, S.; Fu, Y.; Gaelings, L.; Belanov, S.; Yetukuri, L.; Berlinkov, M.; Cheltsov, A.V.; Anders, S.; Aittokallio, T.; Nyman, T.A.; Matikainen, S.; Kainov, D.E. Multi-Omics Studies towards Novel Modulators of Influenza A Virus–Host Interaction. Viruses 2016, 8, 269. Söderholm, S.; Fu, Y.; Gaelings, L.; Belanov, S.; Yetukuri, L.; Berlinkov, M.; Cheltsov, A.V.; Anders, S.; Aittokallio, T.; Nyman, T.A.; Matikainen, S.; Kainov, D.E. Multi-Omics Studies towards Novel Modulators of Influenza A Virus–Host Interaction. Viruses 2016, 8, 269.

Journal reference: Viruses 2016, 8, 269
DOI: 10.3390/v8100269

Abstract

Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 200 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the remaining 665 is unknown. Studying anti-influenza efficacy, immuno-modulating properties and potential resistance of these compounds or their combinations may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics.

Subject Areas

influenza virus; antiviral agent; proteomics; phosphoproteomics; metabolomics; transcriptomics; genomics; virtual ligand screening

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