Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India
Institute of Sciences of Food Productions, CNR-ISPA, Lecce, Italy
Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, P.O. Box 26666, Sharjah, United Arab Emirates
: Received: 1 August 2016 / Approved: 2 August 2016 / Online: 2 August 2016 (09:02:09 CEST)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to cite:
Narasimhan, S.; Maheshwaran, S.; Poltronieri, P.; Abu-Yousef, I.; Majdalawieh, A.; Rethavathi, J.; Das, P. Potential Application of Modified α-Mangostin Xanthones from Garcinia mangostana as Antibacterial Agents in Food Packaging. Preprints2016, 2016080013 (doi: 10.20944/preprints201608.0013.v1).
Narasimhan, S.; Maheshwaran, S.; Poltronieri, P.; Abu-Yousef, I.; Majdalawieh, A.; Rethavathi, J.; Das, P. Potential Application of Modified α-Mangostin Xanthones from Garcinia mangostana as Antibacterial Agents in Food Packaging. Preprints 2016, 2016080013 (doi: 10.20944/preprints201608.0013.v1).
The microbial contamination in food packaging have been a major concern that paved the way for the search for natural based new anti-microbial agents, such as modified α-mangostin. In the present work, twelve synthetic analogs were obtained via semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher therapeutic value than the parent molecule. The anti-microbial studies proved that I E showed higher antibacterial activity whereas I I showed most significant antifungal activity. Due to their microbial properties, modified α-mangostin can be utilized as active anti-microbial agents in food packaging.